Scenario: Maria has cultured SAOS-2 osteosarcoma cancer cells. She treats the cells with a chemotherapy reagent. After a few weeks of treatment, she removes the chemotherapy drug and releases the cells into their normal growth medium. She notes that a subpopulation of cells continue to grow. Which one of the following observations is MOST probable in downstream assessments? Group of answer choices The cells will eventually go through apoptosis. The cells will show a gain-of-function mutation in a growth factor repector. The cells will have a significantly reduced response to the original chemotherapy reagent. The cells will show an enhanced response to the chemotherapy reagent used in the original experiment.
Question
Scenario: Maria has cultured SAOS-2 osteosarcoma cancer cells. She treats the cells with a chemotherapy reagent. After a few weeks of treatment, she removes the chemotherapy drug and releases the cells into their normal growth medium. She notes that a subpopulation of cells continue to grow. Which one of the following observations is MOST probable in downstream assessments?
Group of answer choices
The cells will eventually go through apoptosis.
The cells will show a gain-of-function mutation in a growth factor repector.
The cells will have a significantly reduced response to the original chemotherapy reagent.
The cells will show an enhanced response to the chemotherapy reagent used in the original experiment.
Solution
The most probable observation in downstream assessments is that the cells will have a significantly reduced response to the original chemotherapy reagent. This is because the subpopulation of cells that continued to grow after the chemotherapy treatment were likely resistant to the drug. This resistance could be due to a variety of mechanisms, such as increased drug efflux, alterations in the drug target, or enhanced DNA repair. Therefore, if the same chemotherapy reagent is used again, these cells are likely to show a reduced response.
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