Tumours that have efficiently down regulated the expression of MHC molecules can still get cleared by which of these cells Group of answer choices CD4 T cells CD8 T cells NK cells T regulatory cells
Question
Tumours that have efficiently down regulated the expression of MHC molecules can still get cleared by which of these cells Group of answer choices
CD4 T cells
CD8 T cells
NK cells
T regulatory cells
Solution
The answer is NK cells.
Here's why:
Major Histocompatibility Complex (MHC) molecules are crucial for the immune system's ability to recognize foreign substances. They present antigens to T cells, which then trigger an immune response.
CD4 T cells and CD8 T cells both rely on MHC molecules to recognize and respond to antigens. CD4 T cells interact with MHC class II molecules, while CD8 T cells interact with MHC class I molecules. If a tumor has downregulated the expression of MHC molecules, these T cells would not be able to recognize and respond to the tumor cells.
T regulatory cells, on the other hand, are involved in suppressing the immune response to prevent an overreaction. They would not be involved in clearing tumor cells.
Natural Killer (NK) cells, however, do not rely on MHC molecules to recognize and kill their targets. Instead, they are able to recognize and kill cells that lack MHC molecules, such as some tumor cells. Therefore, tumors that have efficiently downregulated the expression of MHC molecules can still get cleared by NK cells.
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