Poor metabolizers of tamoxifen should be:Question 24Answera.Given another medicationb.Given a dose similar to that of raid metabolizerc.Given a dose lower than raid metabolizerd.Given a dose higher than raid metabolizer

The correct answer is a. Given another medication.

Tamoxifen is a prodrug, which means it needs to be metabolized in the body to become active. It is metabolized by the enzyme CYP2D6 into its active form.

People who are poor metabolizers of tamoxifen have a variant of the CYP2D6 gene that results in reduced or absent enzyme activity. This means that they cannot effectively convert tamoxifen into its active form, which can lead to reduced effectiveness of the drug.

Therefore, poor metabolizers of tamoxifen should be given another medication that does not rely on CYP2D6 for activation. This ensures that they receive effective treatment for their condition.