Before a meal, when blood glucose drops 10% below its resting value, which glucose transporter is working closest to Vmax?Group of answer choicesGLUT2, because it has a very high Kt, which helps regulate insulin production and removal of glucose from the blood.GLUT4, because its Kt is most similar to normal blood glucose levels.GLUT1, because it has a moderately low Kt, which provides a constant flow of glucose into most cells of the body to maintain their basal cellular functions.GLUT3, because it has a very low Kt, which protects glucose supply to the brain.
Question
Before a meal, when blood glucose drops 10% below its resting value, which glucose transporter is working closest to Vmax?Group of answer choicesGLUT2, because it has a very high Kt, which helps regulate insulin production and removal of glucose from the blood.GLUT4, because its Kt is most similar to normal blood glucose levels.GLUT1, because it has a moderately low Kt, which provides a constant flow of glucose into most cells of the body to maintain their basal cellular functions.GLUT3, because it has a very low Kt, which protects glucose supply to the brain.
Solution
The correct answer is: GLUT3, because it has a very low Kt, which protects glucose supply to the brain.
Here's a step-by-step explanation:
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GLUT transporters are a family of proteins that facilitate the transport of glucose across the cell membrane. Each GLUT transporter has a different affinity for glucose, which is represented by its Michaelis constant (Kt).
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A lower Kt value means a higher affinity for glucose, meaning the transporter can function efficiently even when glucose concentrations are low.
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GLUT3 has a very low Kt, meaning it has a high affinity for glucose. This allows it to continue transporting glucose into cells even when blood glucose levels drop.
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This is particularly important for the brain, which relies heavily on glucose for energy. Therefore, GLUT3 ensures a constant supply of glucose to the brain, even when blood glucose levels are low.
The other options - GLUT2, GLUT4, and GLUT1 - have higher Kt values, meaning they have lower affinities for glucose and are less efficient at transporting glucose when its concentration in the blood is low.
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