the major form of disposal of amino group?

The major form of disposal of the amino group in humans is through the urea cycle. Here are the steps:

1. Transamination: The amino group is transferred from the amino acid to a keto acid, usually alpha-ketoglutarate. This forms glutamate and a new keto acid.

2. Oxidative deamination: The amino group of glutamate is removed as ammonia (NH3) by the enzyme glutamate dehydrogenase. This forms alpha-ketoglutarate again.

3. Urea cycle: The ammonia is converted to urea in the liver. This involves a series of reactions that combine ammonia with carbon dioxide to form urea. The urea is then excreted in the urine.

This process allows the body to get rid of excess nitrogen while also recycling the keto acids for energy production.