Pertaining to psoriasis, which of the following statements is/are correct?W. It is characterised by hyperplasia of the epidermis (outermost layer of skin).X. The aetiology/pathogenesis involves both genetics and autoimmunityY. It is a disease characterised by cells undergoing a pathological adaptation.Z. It is typically an iatrogenic disease.Question 20Select one:a.Only W, X, and Y are correct.b.Only W and Y are correct.c.Only X and Z are correct.d.Only Z is correct.e.All are correct.

Which of the following statements is/are correct in relation to Hypersensitivity (HS) reactions?W. HS reactions may be fatal in certain circumstances.X. Activation of Antibodies, complement and T-cells may all lead to tissue damage in HS reactions.Y.  HS reactions involve cells of the immune system.Z. HS reactions involve an excessive immune response against a specific antigen.Question 22Select one:a.Only W, X, and Y are correct.b.Only W and Y are correct.c.Only X and Z are correct.d.Only Z is correct.e.All are correct.

Which of the following statements is/are correct?W. Bacteria will typically stimulate an infiltrate of both neutrophils and macrophages in affected tissue.X. A bacterial infection will typically lead to a serous exudate.Y. Viruses typically stimulate an infiltrate of both lymphocytes and macrophages.Z. Viruses will typically stimulate an acute, rather than chronic, inflammatory response from onset.Question 21Select one:a.Only W, X, and Y are correct.b.Only W and Y are correct.c.Only X and Z are correct.d.Only Z is correct.e.All are correct.

Which of the following diseases is/are correctly matched to its pathogenesis?W. Osteoarthritis - chronic inflammation and hypersensitivity reactionsX. Rickets - bones are poorly mineralized and soft.Y.  Rheumatoid Arthritis - asymmetrical development in joints of hands and feet.Z. Osteomalacia - bones are poorly mineralized and soft.Question 15Select one:a.if only W, X and Y are correctb.if only W and Y are correctc.if only X and Z are correctd.if only Z is correcte.if all are correct

Which of the following statements is/are correct in relation to rheumatoid arthritis (RA)?W. RA is a chronic inflammatory disease that principally affects joints.X. The concentrations (titres) of Rheumatoid Factor deposited in joints does not influence disease severity.Y. The pathogenesis of joint destruction in RA involves both Type III and Type IV hypersensitivity reactions.Z. Development of RA greatly depends on repetitive impulse loading.Question 35Select one:a.if only W, X and Y are correctb.if only W and Y are correctc.if only X and Z are correctd.if only Z is correcte.if all are correct

Which of the following statements apply to asthma?W. An individual’s genetic make-up does not influence the disease.X.   Is typically largely asymptomatic until triggered by an allergen.Y.   Attacks are usually due to rapid dilation of bronchi.Z.   Is a classic example of a Gene-Environment Interaction (GEI).Question 52Select one:a.if only W, X and Y are correctb.if only W and Y are correctc.if only X and Z are correctd.if only Z is correcte.if all are correct