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What is the MOST proven cause of recurrent pregnancy loss (RPL)?A Luteal phase deficiencyB Listeria monocytogenes exposureC Uterine anomaliesD Parental chromosomal abnormalitiesE Environmental toxins

Question

What is the MOST proven cause of recurrent pregnancy loss (RPL)?A Luteal phase deficiencyB Listeria monocytogenes exposureC Uterine anomaliesD Parental chromosomal abnormalitiesE Environmental toxins

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Solution

The most proven cause of recurrent pregnancy loss (RPL) is D Parental chromosomal abnormalities.

Here's a step-by-step explanation:

  1. Luteal phase deficiency: While it has been suggested as a possible cause of RPL, the evidence is not strong enough to consider it as the most proven cause.

  2. Listeria monocytogenes exposure: This is a type of bacteria that can cause a serious infection called listeriosis. While it can lead to miscarriage, it is not the most common cause of RPL.

  3. Uterine anomalies: These can contribute to RPL, but they are not the most common cause.

  4. Parental chromosomal abnormalities: This is the most proven cause of RPL. In about 5% of couples with RPL, one partner carries a chromosomal rearrangement which can increase the risk of conceiving embryos with unbalanced chromosome numbers.

  5. Environmental toxins: While exposure to certain environmental toxins can increase the risk of miscarriage, they are not the most proven cause of RPL.

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