which of the following is correctly paired?a) inhibition of PTH- poorly mineralized boneb) vitamin D deficiency- low plasma calcium and phosphorus levelsc) binding of an agonist to the angiotensin II receptor- reduced blood pressured) inhibition of 1 alpha hydroxylase- reduced excretion of calcium
Question
which of the following is correctly paired?a) inhibition of PTH- poorly mineralized boneb) vitamin D deficiency- low plasma calcium and phosphorus levelsc) binding of an agonist to the angiotensin II receptor- reduced blood pressured) inhibition of 1 alpha hydroxylase- reduced excretion of calcium
Solution
The correct pairing is b) vitamin D deficiency- low plasma calcium and phosphorus levels.
Here's why:
a) Inhibition of PTH (Parathyroid Hormone) would actually lead to an increase in bone mineralization, not poorly mineralized bone. This is because PTH is responsible for increasing blood calcium levels by stimulating osteoclasts to break down bone and release calcium.
b) Vitamin D deficiency can indeed lead to low plasma calcium and phosphorus levels. Vitamin D is necessary for the absorption of calcium and phosphorus in the gut. Without it, these minerals cannot be effectively absorbed, leading to their decreased levels in the blood.
c) Binding of an agonist to the angiotensin II receptor would not reduce blood pressure, but rather increase it. Angiotensin II is a potent vasoconstrictor, which means it narrows blood vessels and thus increases blood pressure.
d) Inhibition of 1 alpha hydroxylase would not lead to reduced excretion of calcium. 1 alpha hydroxylase is an enzyme that converts inactive vitamin D to its active form. This active form of vitamin D is necessary for the absorption of calcium in the gut. If this enzyme is inhibited, less calcium would be absorbed and thus more would be excreted, not less.
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