If a wild-type DNA sequence reads AAA ACG CCG AGG, what type of mutation would change it to AAA ACC CCG AGG?ANSWERFrameshiftDeletionMissenseInsertion
Question
If a wild-type DNA sequence reads AAA ACG CCG AGG, what type of mutation would change it to AAA ACC CCG AGG?ANSWERFrameshiftDeletionMissenseInsertion
Solution
To determine the type of mutation that changes the wild-type DNA sequence from AAA ACG CCG AGG to AAA ACC CCG AGG, follow these steps:
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Identify the original sequence: AAA ACG CCG AGG
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Identify the mutated sequence: AAA ACC CCG AGG
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Compare the sequences:
- Original: AAA ACG CCG AGG
- Mutated: AAA ACC CCG AGG
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Locate the change: The second triplet changes from ACG to ACC.
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Determine the type of mutation:
- Frameshift: This involves insertion or deletion of nucleotides that are not in multiples of three, causing a shift in the reading frame. This is not the case here.
- Deletion: This involves the removal of one or more nucleotides. This is not the case here.
- Missense: This involves a single nucleotide change that results in a codon that codes for a different amino acid. This is the case here.
- Insertion: This involves the addition of one or more nucleotides. This is not the case here.
The correct answer is Missense.
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