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Which of the following medications used for allergic rhinitis is a prodrug (active after metabolism), for which we should be aware of concurrent use of other medications that might alter drug metabolism and effect:Question 17Answera.Fexofenadineb.Cetirizinec.Pseudoephedrined.Loratidine

Question

Which of the following medications used for allergic rhinitis is a prodrug (active after metabolism), for which we should be aware of concurrent use of other medications that might alter drug metabolism and effect:Question 17Answera.Fexofenadineb.Cetirizinec.Pseudoephedrined.Loratidine

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Solution

Para responder a esta pregunta, primero debemos entender qué es un prodrug. Un prodrug es un medicamento que, después de ser administrado, se metaboliza en el cuerpo para convertirse en una forma activa. Esto significa que su efectividad puede verse afectada por otros medicamentos que alteren su metabolismo.

Vamos a analizar cada una de las opciones:

a. Fexofenadina: Este medicamento es un antihistamínico de segunda generación que no es un prodrug. Se administra en su forma activa.

b. Cetirizina: También es un antihistamínico de segunda generación y se administra en su forma activa, no es un prodrug.

c. Pseudoefedrina: Es un descongestionante que se administra en su forma activa y no es un prodrug.

d. Loratadina: Este es un antihistamínico de segunda generación que es un prodrug. Se metaboliza en el hígado para convertirse en desloratadina, que es la forma activa.

Por lo tanto, la respuesta correcta es:

d. Loratadina

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