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We identify 50 patients with cancer, review their medical records, and determine that 10 of them were exposed to a risk factor.We then identify a comparison group of 50 cancer-free individuals, review their medical records, and determine that 2 were exposed to the risk factor. Which of the following statements are correct?Group of answer choicesThis is a retrospective studyThe risk factor causes cancer.Patients with the risk factor are 6 times more likely to develop cancer than patients without the risk factor (where likely is interpreted as a probability)This is a prospective studyThe odds of developing cancer for patients with the risk factor are 6 times the odds of developing cancer for those without the risk factor

Question

We identify 50 patients with cancer, review their medical records, and determine that 10 of them were exposed to a risk factor.We then identify a comparison group of 50 cancer-free individuals, review their medical records, and determine that 2 were exposed to the risk factor. Which of the following statements are correct?Group of answer choicesThis is a retrospective studyThe risk factor causes cancer.Patients with the risk factor are 6 times more likely to develop cancer than patients without the risk factor (where likely is interpreted as a probability)This is a prospective studyThe odds of developing cancer for patients with the risk factor are 6 times the odds of developing cancer for those without the risk factor

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Solution

The correct statements are:

  1. This is a retrospective study: This is correct because the study is looking back at existing data (medical records) to identify exposure to a risk factor and the presence of cancer.

  2. The risk factor causes cancer: This statement is not necessarily correct. The study shows a correlation between the risk factor and cancer, but it does not prove causation. Further studies would be needed to establish a causal relationship.

  3. Patients with the risk factor are 6 times more likely to develop cancer than patients without the risk factor: This statement is incorrect. The study shows that 10 out of 50 cancer patients were exposed to the risk factor, compared to 2 out of 50 cancer-free individuals. This means that cancer patients are 5 times more likely to have been exposed to the risk factor, not 6 times.

  4. This is a prospective study: This statement is incorrect. A prospective study would involve identifying individuals, determining their exposure to the risk factor, and then following them over time to see who develops cancer. This study is looking back at existing data, so it is retrospective, not prospective.

  5. The odds of developing cancer for patients with the risk factor are 6 times the odds of developing cancer for those without the risk factor: This statement is incorrect. The odds ratio is calculated as (10/40)/(2/48) = 5, so the odds of developing cancer for patients with the risk factor are 5 times the odds for those without the risk factor, not 6 times.

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