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Which of the following drugs is contraindicated in a patient with hyperkalemia?A. AcetazolamideB. ChlorothiazideC. Ethacrynic acidD. ChlorthalidoneE. Spironolactone

Question

Which of the following drugs is contraindicated in a patient with hyperkalemia?A. AcetazolamideB. ChlorothiazideC. Ethacrynic acidD. ChlorthalidoneE. Spironolactone

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Solution

The correct answer is E. Spironolactone.

Here's why:

Hyperkalemia is a condition characterized by high levels of potassium in the blood.

A. Acetazolamide, B. Chlorothiazide, C. Ethacrynic acid, and D. Chlorthalidone are all diuretics, which are medications that help promote diuresis, i.e., increased production of urine. These drugs can help to remove excess fluid from the body, which can be beneficial in conditions such as heart failure, liver disease, or kidney disease. They do not typically affect potassium levels to a significant degree.

E. Spironolactone, on the other hand, is a potassium-sparing diuretic. This means that it helps to remove excess fluid from the body while still retaining potassium. In a patient with hyperkalemia, who already has high levels of potassium in the blood, this could potentially exacerbate the condition. Therefore, spironolactone is contraindicated in patients with hyperkalemia.

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