Choose the single CORRECT answer or statement. A 55-year-old man with high blood pressure and high cholesterol dies after a thrombus forms on an ulcerated atherosclerotic plaque. Which component of Virchow's triad was most likely to have led to the man's sudden death?Group of answer choicesEndothelial injuryAbnormal blood flowHypercoagulabilityEmbolism
Question
Choose the single CORRECT answer or statement. A 55-year-old man with high blood pressure and high cholesterol dies after a thrombus forms on an ulcerated atherosclerotic plaque. Which component of Virchow's triad was most likely to have led to the man's sudden death?Group of answer choicesEndothelial injuryAbnormal blood flowHypercoagulabilityEmbolism
Solution
The correct answer is Endothelial injury.
Here's why:
Virchow's triad refers to the three broad categories of factors that are thought to contribute to thrombosis:
- Hypercoagulability
- Hemodynamic changes (stasis, turbulence)
- Endothelial injury/dysfunction
In the context of the question, a man with high blood pressure and high cholesterol is likely to have atherosclerotic plaques. These plaques can cause injury to the endothelial cells lining the blood vessels. When an atherosclerotic plaque ruptures or ulcerates, it exposes the underlying endothelium and triggers the coagulation cascade, leading to thrombus formation.
Therefore, in this case, the endothelial injury caused by the ulcerated atherosclerotic plaque most likely led to the man's sudden death.
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