After a meal, when blood glucose spikes to over 10 mM, which glucose transporter is working furthest from its Vmax?Group of answer choicesGLUT3, because it has a very low Kt, which protects glucose supply to the brain.GLUT2, because it has a very high Kt, which helps regulate insulin production and removal of glucose from the blood.GLUT1, because it has a moderately low Kt, which provides a constant flow of glucose into most cells of the body to maintain their basal cellular functions.GLUT4, because its Kt is most similar to normal blood glucose levels.
Question
After a meal, when blood glucose spikes to over 10 mM, which glucose transporter is working furthest from its Vmax?Group of answer choicesGLUT3, because it has a very low Kt, which protects glucose supply to the brain.GLUT2, because it has a very high Kt, which helps regulate insulin production and removal of glucose from the blood.GLUT1, because it has a moderately low Kt, which provides a constant flow of glucose into most cells of the body to maintain their basal cellular functions.GLUT4, because its Kt is most similar to normal blood glucose levels.
Solution
GLUT2, because it has a very high Kt, which helps regulate insulin production and removal of glucose from the blood.
Here's a step-by-step explanation:
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GLUT2 is a glucose transporter that is found in the liver and pancreatic cells. It plays a key role in regulating blood glucose levels and insulin production.
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The Kt value of a transporter is a measure of its affinity for its substrate. A high Kt value means that the transporter has a low affinity for its substrate, and vice versa.
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After a meal, when blood glucose levels spike to over 10 mM, GLUT2 is working furthest from its Vmax because its high Kt value means that it has a low affinity for glucose. This means that it requires a high concentration of glucose to be fully active.
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The high Kt value of GLUT2 allows it to respond to changes in blood glucose levels. When blood glucose levels are high, GLUT2 transports more glucose into the liver and pancreatic cells. This triggers the release of insulin, which helps to lower blood glucose levels.
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Therefore, after a meal, when blood glucose spikes to over 10 mM, GLUT2 is working furthest from its Vmax.
So, the correct answer is "GLUT2, because it has a very high Kt, which helps regulate insulin production and removal of glucose from the blood".
Similar Questions
After a carbohydrate-rich meal, when the blood glucose concentration more than doubles, which of the following glucose transporters would be operating closest to its Vmax? A. GLUT4, because its Kt is most similar to normal blood glucose levels. B. GLUT3, because it has a very low Kt, which protects the brain under starvation conditions. C. GLUT2, because it has a very high Kt, which helps regulate insulin production and removal of glucose from the blood. D. GLUT1, because it has a moderately low Kt, which provides a constant flow of glucose into most cells of the body to maintain their basal cellular functions.
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Le GLUT-2 est un transporteur du glucose qui :AEst exprimé dans le cerveau, les érythrocytes et le placentaBPossède un KM faible (1.6 mmol/l)CRend le transport du glucose optimal quelles que soient les valeurs glycémiquesDEst exprimé dans les cellules β du pancréasEEst associé à la membrane de vésicules intra cytoplasmiques au repos
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