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A 72-year-old man comes to the office for follow-up 2 weeks after starting lisinopril because of headache and increased blood pressure. He has a history of coronary artery disease, hypertension, peripheral artery disease, and hyperlipidemia. In addition to lisinopril, he takes amlodipine, metoprolol, atorvastatin, and low-dose aspirin. He quit smoking 5 months ago; he previously smoked 1 pack of cigarettes daily for the past 40 years. BMI is 25 kg/m2. His pulse is 84/min and regular, and blood pressure is 165/94 mm Hg. Lower extremity pulses are 2+ on the left and 1+ on the right. There is no peripheral edema. Cardiopulmonary auscultation discloses clear breath sounds bilaterally and no murmurs or gallops. The abdomen is nontender to palpation with no distention. Laboratory studies from today and 2 weeks ago are shown:  Today 2 Weeks AgoSodium (mEq/L) 137 142Potassium (mEq/L) 3.9 3.1Chloride (mEq/L) 101 98Bicarbonate (mEq/L) 25 30Creatinine (mg/dL) 2.1 1.4Glucose (mg/dL) 95 82Which of the following studies is most likely to confirm the underlying cause of these symptoms?A. Dexamethasone suppression testB. Kidney biopsyC. Measurement of plasma and urine metanephrine concentrationsD. Measurement of serum aldosterone concentrationE. Renal Doppler ultrasonographyF. Urinalysis

Question

A 72-year-old man comes to the office for follow-up 2 weeks after starting lisinopril because of headache and increased blood pressure. He has a history of coronary artery disease, hypertension, peripheral artery disease, and hyperlipidemia. In addition to lisinopril, he takes amlodipine, metoprolol, atorvastatin, and low-dose aspirin. He quit smoking 5 months ago; he previously smoked 1 pack of cigarettes daily for the past 40 years. BMI is 25 kg/m2. His pulse is 84/min and regular, and blood pressure is 165/94 mm Hg. Lower extremity pulses are 2+ on the left and 1+ on the right. There is no peripheral edema. Cardiopulmonary auscultation discloses clear breath sounds bilaterally and no murmurs or gallops. The abdomen is nontender to palpation with no distention. Laboratory studies from today and 2 weeks ago are shown:  Today 2 Weeks AgoSodium (mEq/L) 137 142Potassium (mEq/L) 3.9 3.1Chloride (mEq/L) 101 98Bicarbonate (mEq/L) 25 30Creatinine (mg/dL) 2.1 1.4Glucose (mg/dL) 95 82Which of the following studies is most likely to confirm the underlying cause of these symptoms?A. Dexamethasone suppression testB. Kidney biopsyC. Measurement of plasma and urine metanephrine concentrationsD. Measurement of serum aldosterone concentrationE. Renal Doppler ultrasonographyF. Urinalysis

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Solution

The patient's symptoms and lab results suggest that he may be experiencing renal artery stenosis, a condition that can be caused by atherosclerosis, which the patient is at risk for due to his history of coronary artery disease, peripheral artery disease, and hyperlipidemia. Renal artery stenosis can lead to activation of the renin-angiotensin-aldosterone system, resulting in hypertension and renal impairment, which could explain the patient's increased blood pressure and elevated creatinine levels.

The best test to confirm this diagnosis would be a Renal Doppler ultrasonography (Choice E). This non-invasive test uses ultrasound to evaluate blood flow to the kidneys and can detect narrowing of the renal arteries. The other tests listed are not as appropriate because they are used to diagnose different conditions. For example, a dexamethasone suppression test is used to diagnose Cushing's syndrome, a kidney biopsy would be more invasive and not first-line, measurement of plasma and urine metanephrine concentrations is used to diagnose pheochromocytoma, measurement of serum aldosterone concentration is used to diagnose primary hyperaldosteronism, and a urinalysis could detect a variety of conditions but would not be specific for renal artery stenosis.

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