Affects of acetylation on histones (lysine)?Select your answer:Select your answerOPTION ALTERNATIVE Adding acetyl group to the end of the histone makes it negative makes the DNA that its associated with more readily transcribed Removes positive charge from the side-chain so weakens the interaction between histones and negatively charged DNA. All of the above
Question
Affects of acetylation on histones (lysine)?Select your answer:Select your answerOPTION ALTERNATIVE Adding acetyl group to the end of the histone makes it negative makes the DNA that its associated with more readily transcribed Removes positive charge from the side-chain so weakens the interaction between histones and negatively charged DNA. All of the above
Solution
The correct answer is "All of the above".
Acetylation of histones, specifically on the lysine residues, has several effects:
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It adds an acetyl group to the end of the histone. This does not make the histone negative, but it does neutralize the positive charge on the lysine residue.
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This modification can make the DNA that is associated with the histone more readily transcribed. This is because the neutralization of the positive charge reduces the affinity between the histone and the negatively charged DNA, allowing the DNA to be more accessible for transcription machinery.
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As mentioned, acetylation removes the positive charge from the side-chain of the lysine residue. This weakens the interaction between the histones and the negatively charged DNA, making the DNA less tightly wound around the histones.
So, all of the statements are correct.
Similar Questions
What is the effect of high levels of histone acetylation on the expression of a gene?Group of answer choicesThis changes the splicing of the geneIt causes the chromatin to condenseThe gene becomes expressed lessThe gene becomes expressed more
How does histone acetylation activate transcription in eukaryotes?Group of answer choicesby increasing the affinity of histone for DNAby recruiting other components of the transcriptional machineryby inhibiting the active remodeling of the chromatin structureall of the abovenone of the above
Histone proteins can be modified through methlyation, acetylation, and phosphorylation. Most oftenit is lysine (K) amino acids that are modified. To investigate the role of the acetylation of a lysine atposition 56 (K56) in histone H3, a mutation was made where the lysine is replaced with an arginineresidue, which prevents acetylation. This mutation is lethal at the embryonic stage.a. What effect would this mutation have on the packing of chromatin? Explain your answer. (2marks)b. What could be the reason that this mutation is lethal? Suggest a reason and explain yourchoice. (3 marks)Questions continue over the page.
Increase in histone deacetylases.B. Increase in histone acetyltransferases.C. Decrease in DNA methyltransferases.D. Decrease in CpG methylation of promoter
In addition to being metabolized for energy, the ketone body β-hydroxybutyrate (BHB) can also react with lysine residues of histone proteins.Which statement best explains the general upregulation of gene expression following histone β-hydroxybutyrylation? β-Hydroxybutyrylation:A.decreases the binding interaction between histones and the DNA backbone.B.increases the binding interaction between histones and the nitrogenous bases of DNA.C.increases the binding interaction between histones and the RNA backbone.D.decreases the binding interaction between histones and the nitrogenous bases of RNA.
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