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In the operation of sodium-potassium ATPase,Select one:Select the correct definitionthere is an obligatory coupling of sodium efflux and potassium influx.this transporter (or "pump") is electrogenic.phosphorylation and dephosphorylation respectively, are associated with the sodium and potassium transport steps.the pump transports two potassium ions for every three sodium ions.

Question

In the operation of sodium-potassium ATPase,Select one:Select the correct definitionthere is an obligatory coupling of sodium efflux and potassium influx.this transporter (or "pump") is electrogenic.phosphorylation and dephosphorylation respectively, are associated with the sodium and potassium transport steps.the pump transports two potassium ions for every three sodium ions.

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Solution

The operation of the sodium-potassium ATPase involves several steps:

  1. There is an obligatory coupling of sodium efflux and potassium influx: This means that the pump always moves sodium ions out of the cell and potassium ions into the cell. This is a simultaneous process, meaning that for every 3 sodium ions that are pumped out, 2 potassium ions are pumped in.

  2. This transporter (or "pump") is electrogenic: This means that the pump creates an electrical gradient across the cell membrane. Because more positive charges are moved out of the cell than are moved in, the inside of the cell becomes more negative relative to the outside.

  3. Phosphorylation and dephosphorylation respectively, are associated with the sodium and potassium transport steps: This means that the pump uses the energy from ATP to move the ions across the membrane. The ATP molecule is broken down (dephosphorylated) to provide the energy for the pump to work, and then it is reformed (phosphorylated) when the pump is ready to work again.

  4. The pump transports two potassium ions for every three sodium ions: This means that for every cycle of the pump, 3 sodium ions are moved out of the cell and 2 potassium ions are moved in. This is what creates the electrical gradient across the cell membrane.

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