Which of the following mRNA strands contains the longest open reading frame?A.5′-CCACGAUGCGUUGAGCGC-3′B.5′-CAAUGGUAAAGUCUUAGU-3′C.5′-GACGAUGUAACUUGCACU-3′D.5′-AGAAUGGUAUCCUGAGCC-3′
Question
Which of the following mRNA strands contains the longest open reading frame?A.5′-CCACGAUGCGUUGAGCGC-3′B.5′-CAAUGGUAAAGUCUUAGU-3′C.5′-GACGAUGUAACUUGCACU-3′D.5′-AGAAUGGUAUCCUGAGCC-3′
Solution
An open reading frame (ORF) in mRNA is a sequence that has the potential to be translated into a protein. It starts with a start codon (AUG) and ends with a stop codon (UAA, UAG, UGA).
Let's examine each option:
A. 5′-CCACGAUGCGUUGAGCGC-3′ The ORF starts at the 7th nucleotide with AUG and ends at the 15th nucleotide with UGA. So, the ORF is 9 nucleotides long.
B. 5′-CAAUGGUAAAGUCUUAGU-3′ The ORF starts at the 4th nucleotide with AUG and ends at the 10th nucleotide with UAA. So, the ORF is 7 nucleotides long.
C. 5′-GACGAUGUAACUUGCACU-3′ The ORF starts at the 6th nucleotide with AUG and there is no stop codon. So, there is no ORF in this sequence.
D. 5′-AGAAUGGUAUCCUGAGCC-3′ The ORF starts at the 4th nucleotide with AUG and there is no stop codon. So, there is no ORF in this sequence.
Therefore, the mRNA strand that contains the longest open reading frame is A. 5′-CCACGAUGCGUUGAGCGC-3′.
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