Why is Anne so upset to hear from Mr. Dussel that Jopie de Waal is gone?*She thinks that Jopie has moved away and they might lose contact.She wonders why Jopie didn't say good-bye to her first.She knows that Jopie and her family have been taken by the Nazis.She had been looking forward to a visit from Jopie.

Anne is so upset to hear from Mr. Dussel that Jopie de Waal is gone because Jopie is her best friend. The news is distressing for several reasons:

1. She thinks that Jopie has moved away and they might lose contact: Anne and Jopie are very close, and the thought of not being able to communicate with her anymore is very upsetting for Anne.

2. She wonders why Jopie didn't say good-bye to her first: This suggests that Anne feels hurt and betrayed. She can't understand why her best friend would leave without saying goodbye.

3. She knows that Jopie and her family have been taken by the Nazis: This is the most distressing reason. Anne is living in hiding from the Nazis, and the news that her best friend has been taken by them is a stark reminder of the danger she and her family are in.

4. She had been looking forward to a visit from Jopie: Anne's life in hiding is monotonous and lonely, and a visit from her best friend would have been a bright spot in her difficult circumstances. The news that Jopie is gone dashes these hopes.