Regarding the major histocompatibility class II (MHC II) molecule, which of the following statements is TRUE?Select one alternative:Each MHC II molecule can present only one specific (cognate) antigen.MHC II molecules present endogenous antigens, from within the cell.MHC II is expressed on all nucleated cells in the body.Antigenic peptides are anchored along the peptide binding groove in MHC II.
Question
Regarding the major histocompatibility class II (MHC II) molecule, which of the following statements is TRUE?Select one alternative:Each MHC II molecule can present only one specific (cognate) antigen.MHC II molecules present endogenous antigens, from within the cell.MHC II is expressed on all nucleated cells in the body.Antigenic peptides are anchored along the peptide binding groove in MHC II.
Solution 1
The correct statement is: "Antigenic peptides are anchored along the peptide binding groove in MHC II."
Here's why:
-
Each MHC II molecule can present only one specific (cognate) antigen: This statement is false. MHC II molecules can present a variety of antigens, not just one specific one.
-
MHC II molecules present endogenous antigens, from within the cell: This statement is false. MHC II molecules present exogenous antigens, which are derived from outside the cell. Endogenous antigens are presented by MHC I molecules.
-
MHC II is expressed on all nucleated cells in the body: This statement is false. MHC II is not expressed on all nucleated cells. It is primarily expressed on antigen-presenting cells (APCs) like macrophages, dendritic cells, and B cells.
-
Antigenic peptides are anchored along the peptide binding groove in MHC II: This statement is true. The antigenic peptides are indeed anchored along the peptide-binding groove of the MHC II molecule, allowing them to be recognized by T-cell receptors.
Solution 2
The correct statement is: "Antigenic peptides are anchored along the peptide binding groove in MHC II."
Here's why:
-
Each MHC II molecule can present only one specific (cognate) antigen: This statement is false. MHC II molecules can present a variety of antigens, not just one specific one.
-
MHC II molecules present endogenous antigens, from within the cell: This statement is false. MHC II molecules present exogenous antigens, which are derived from outside the cell. Endogenous antigens are presented by MHC I molecules.
-
MHC II is expressed on all nucleated cells in the body: This statement is false. MHC II is not expressed on all nucleated cells. It is primarily expressed on antigen-presenting cells (APCs) like macrophages, dendritic cells, and B cells.
-
Antigenic peptides are anchored along the peptide binding groove in MHC II: This statement is true. The antigenic peptides are indeed anchored along the peptide-binding groove of the MHC II molecule. This allows the T cell receptor to recognize and bind to the antigen-MHC II complex.
Similar Questions
The major histocompatibility complex type I (MHC I) __________.ANSWERinteracts with CD4 on T helper cellsis found only on antigen-presenting cellsis found on all body cells except red blood cellspresents extracellular antigens
Describe how do Class II Major Histocompatibility Complex receptors (MHC-II receptors) work.
Which of the following is NOT considered as professional antigen presenting cells expressing MHC Class II?Thyroid epithelial cellsB cellsMacrophagesDendritic cells
MHC class I is BEST DESCRIBED by which statement?Select one alternative:It presents viral peptides to CD8 T cells.It presents foreign peptides to CD4 T cells.It captures foreign peptides from extracellular pathogens.It is only expressed on specialised antigen presenting cells.
Which of the following statements is true?Macrophages do not express any MHC molecules on their surface.Macrophages express both class I and class II MHC molecules.Macrophages only express class I MHC molecules.Macrophages only express class II MHC molecules.
Upgrade your grade with Knowee
Get personalized homework help. Review tough concepts in more detail, or go deeper into your topic by exploring other relevant questions.