Which of the following correctly describes the stereospecific formation of a citric acid cycle intermediate?A.Citrate synthase consumes ATP to generate citrate from oxaloacetate and acetyl-CoA.B.Fumarase converts fumarate into both l- and d-malate through a condensation reaction.C.Succinyl-CoA synthetase consumes GTP to transform succinyl-CoA to succinate.D.Aconitase converts citrate into isocitrate through an intermediate.
Question
Which of the following correctly describes the stereospecific formation of a citric acid cycle intermediate?A.Citrate synthase consumes ATP to generate citrate from oxaloacetate and acetyl-CoA.B.Fumarase converts fumarate into both l- and d-malate through a condensation reaction.C.Succinyl-CoA synthetase consumes GTP to transform succinyl-CoA to succinate.D.Aconitase converts citrate into isocitrate through an intermediate.
Solution
The correct answer is D. Aconitase converts citrate into isocitrate through an intermediate.
Here's the step-by-step explanation:
A. Citrate synthase does not consume ATP to generate citrate from oxaloacetate and acetyl-CoA. Instead, it catalyzes a condensation reaction between acetyl-CoA and oxaloacetate to form citrate, without the need for ATP.
B. Fumarase does convert fumarate into malate, but it does not produce both l- and d-malate. It specifically catalyzes the hydration of fumarate to l-malate.
C. Succinyl-CoA synthetase does not consume GTP to transform succinyl-CoA to succinate. Instead, it catalyzes the conversion of succinyl-CoA to succinate, and in the process, it generates GTP (or ATP in some organisms).
D. Aconitase does convert citrate into isocitrate through an intermediate. This is a two-step reaction where citrate is first converted to cis-aconitate (the intermediate), and then cis-aconitate is converted to isocitrate. This is a stereospecific reaction as it specifically produces isocitrate, not its stereoisomer citrate.
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