The pathophysiological change of full thickness burn includesincreased vascular permeability from the release of inflammatory mediatorspain due to the activation of nociceptors at the nerve endingsmoist skin due to increased vascular permeability  and increased tissue perfusion blanching skin due to increased blood flow to the skin

The pathophysiological changes in a full-thickness burn involve several steps:

1. Increased Vascular Permeability: Inflammatory mediators are released in response to the burn injury. These mediators cause the blood vessels in the affected area to become more permeable, allowing fluid and immune cells to leak into the tissues. This can lead to swelling and inflammation.

2. Pain: The burn injury can activate nociceptors, which are sensory receptors for pain, at the nerve endings in the skin. This results in the sensation of pain.

3. Moist Skin: The increased vascular permeability can also lead to moist skin. This is because the fluid that has leaked out of the blood vessels can accumulate in the skin tissues, making the skin feel wet or moist.

4. Increased Tissue Perfusion: The body may respond to the burn injury by increasing the amount of blood that is being delivered to the affected area. This is known as increased tissue perfusion. It is the body's way of trying to deliver more oxygen and nutrients to the damaged tissues to aid in healing.

5. Blanching Skin: The increased blood flow to the skin can cause the skin to appear blanched, or pale. This is because the blood vessels in the skin are dilating, or widening, to allow more blood to flow through them. This can make the skin look paler than usual.

These are the main pathophysiological changes that occur in a full-thickness burn. However, the exact changes can vary depending on the severity and location of the burn, as well as the individual's overall health.