In the pathogenesis of Multiple Sclerosis:Question 59Select one:a.All these answers are correct.b.Inflammation (mediated by macrophages and lymphocytes) leads to myelin and axon destruction.c.Regions of brain tissue are replaced with connective tissue, i.e. "scarring".d.Attempted regeneration may occur in a shadow plaque.e.Plaques develop in the brain that may increase in size over time.
Question
In the pathogenesis of Multiple Sclerosis:Question 59Select one:a.All these answers are correct.b.Inflammation (mediated by macrophages and lymphocytes) leads to myelin and axon destruction.c.Regions of brain tissue are replaced with connective tissue, i.e. "scarring".d.Attempted regeneration may occur in a shadow plaque.e.Plaques develop in the brain that may increase in size over time.
Solution
The correct answer is a. All these answers are correct.
Here's why:
b. Inflammation (mediated by macrophages and lymphocytes) leads to myelin and axon destruction: This is true. In Multiple Sclerosis (MS), the immune system mistakenly attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body.
c. Regions of brain tissue are replaced with connective tissue, i.e. "scarring": This is also true. In MS, the immune system's attack on the myelin causes inflammation and injury to the myelin and underlying nerves, resulting in plaques or scars.
d. Attempted regeneration may occur in a shadow plaque: This is true as well. Shadow plaques are areas of the brain where there has been partial remyelination or repair after an MS attack.
e. Plaques develop in the brain that may increase in size over time: This is also correct. In MS, the damaged areas (plaques) can increase in size over time as the disease progresses.
So, all the statements are correct about the pathogenesis of Multiple Sclerosis.
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