A normal couple has a child that was diagnosed with Tay-Sachs. Identify the genotype of the parents [1]Use a punnett square to illustrate the potential genotype of the offsprings [4]Offspring genotypic ratios [1]Offspring phenotypic ratios [1]
Question
A normal couple has a child that was diagnosed with Tay-Sachs. Identify the genotype of the parents [1]Use a punnett square to illustrate the potential genotype of the offsprings [4]Offspring genotypic ratios [1]Offspring phenotypic ratios [1]
Solution
- Identifying the genotype of the parents:
Tay-Sachs is a recessive genetic disorder, which means that both parents must carry the gene for a child to be affected. Therefore, the genotype of both parents would be heterozygous, or Tt, where T is the normal allele and t is the Tay-Sachs allele.
- Using a Punnett square to illustrate the potential genotype of the offspring:
A Punnett square is a diagram used to predict the outcome of a particular cross or breeding experiment. Here's how the Punnett square would look for this couple:
| T | t | |
|---|---|---|
| T | TT | Tt |
| t | Tt | tt |
- Offspring genotypic ratios:
From the Punnett square, we can see that the genotypic ratio of the offspring would be 1 TT : 2 Tt : 1 tt.
- Offspring phenotypic ratios:
In terms of phenotypes, TT and Tt would both result in a normal phenotype because T is dominant. tt would result in the Tay-Sachs phenotype. Therefore, the phenotypic ratio would be 3 normal : 1 Tay-Sachs.
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