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Hyperglycaemia, a feature of poorly treated diabetes mellitus, can result in: Question 11Answera.Microangiopathy.b.Increased basement membrane production in capillaries by endothelial cells.c.Loss of plasma proteins and glucose due to increased blood vessel permeability.d.Sensory neuropathy due to excess glucose uptake by neurons.e.All of the above.

Question

Hyperglycaemia, a feature of poorly treated diabetes mellitus, can result in: Question 11Answera.Microangiopathy.b.Increased basement membrane production in capillaries by endothelial cells.c.Loss of plasma proteins and glucose due to increased blood vessel permeability.d.Sensory neuropathy due to excess glucose uptake by neurons.e.All of the above.

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Solution

The correct answer is e. All of the above.

Here's why:

a. Microangiopathy: High blood sugar levels in diabetes damage the small blood vessels, leading to a condition called microangiopathy.

b. Increased basement membrane production in capillaries by endothelial cells: Hyperglycemia can cause thickening of the basement membrane in capillaries, which is produced by endothelial cells.

c. Loss of plasma proteins and glucose due to increased blood vessel permeability: High blood sugar levels can increase the permeability of blood vessels, leading to loss of plasma proteins and glucose.

d. Sensory neuropathy due to excess glucose uptake by neurons: High blood sugar levels can damage nerves, leading to sensory neuropathy.

So, all of the mentioned conditions can be a result of poorly treated diabetes mellitus, which is characterized by hyperglycemia.

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