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Persons with Marfan syndrome have disproportionately long arms, legs, hands, and feet, a weakened aorta, and poor eyesight. All of these characteristics are due to a mutated gene (FBN1) on chromosome 15 that ordinarily specifies a functional protein called flbrillin. This is an example of _____.Group of answer choicespleiotropyepistasismultifactorialpolygeniccodominanceNext

Question

Persons with Marfan syndrome have disproportionately long arms, legs, hands, and feet, a weakened aorta, and poor eyesight. All of these characteristics are due to a mutated gene (FBN1) on chromosome 15 that ordinarily specifies a functional protein called flbrillin. This is an example of _____.Group of answer choicespleiotropyepistasismultifactorialpolygeniccodominanceNext

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Solution

This is an example of pleiotropy. Pleiotropy refers to a single gene that influences multiple, seemingly unrelated phenotypic traits. In this case, the mutated FBN1 gene is causing a variety of symptoms including long arms, legs, hands, and feet, a weakened aorta, and poor eyesight.

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Marfan syndrome is a dominant disorder characterized by extreme flexibility, height and weak connective tissue. However, not all of the individuals with a genotype for this condition display the phenotype. We would describe this disorder as one with ___.Group of answer choicesgenomic imprintingvariable expressivitycodominanceincomplete penetrance

Marfan syndrome is the result of inheriting a single allele. Individuals with Marfan syndrome are tall and long-limbed, and have both cardiovascular and eye defects. Marfan syndrome is an example of ________.homozygous recessivepleiotropyincomplete dominancecodominance

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A human genetic disease usually caused by the presence of an extra chromosome 21; characterized by developmental delays and heart and other defects that are generally treatable or non-life-threatening.Group of answer choicesHuntington’s diseasehemophiliasickle-cell diseaseTay-Sachs diseaseDown syndromeDuchenne muscular dystrophyNext

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