Which statements are true about the pathogenesis of Systemic Lupus Erythematosus? Select all that apply:(Required) A. The phagocytosis process is not occurring properly, which causes the nuclear material inside the dying cell to be seen as a foreign invader and antinuclear antibodies are created. B. During cell death the nucleus of the cell fails to condense, which leads to the development of autoantibodies. C. Immune complexes form and attach within the structures of important organs, joints, and tissues, and this causes inflammation. D. Neutrophil activity is decreased and this causes B-cells to attack phagocytes and nuclear material within the cells, which leads to the activation of the complement cascade system and inflammation.
Question
Which statements are true about the pathogenesis of Systemic Lupus Erythematosus? Select all that apply:(Required) A. The phagocytosis process is not occurring properly, which causes the nuclear material inside the dying cell to be seen as a foreign invader and antinuclear antibodies are created. B. During cell death the nucleus of the cell fails to condense, which leads to the development of autoantibodies. C. Immune complexes form and attach within the structures of important organs, joints, and tissues, and this causes inflammation. D. Neutrophil activity is decreased and this causes B-cells to attack phagocytes and nuclear material within the cells, which leads to the activation of the complement cascade system and inflammation.
Solution
The statements that are true about the pathogenesis of Systemic Lupus Erythematosus are:
A. The phagocytosis process is not occurring properly, which causes the nuclear material inside the dying cell to be seen as a foreign invader and antinuclear antibodies are created.
B. During cell death the nucleus of the cell fails to condense, which leads to the development of autoantibodies.
C. Immune complexes form and attach within the structures of important organs, joints, and tissues, and this causes inflammation.
The statement D is not entirely accurate. While neutrophil activity can be abnormal in SLE, it's not typically characterized by decreased neutrophil activity leading to B-cells attacking phagocytes and nuclear material within the cells. Instead, abnormalities in the immune system lead to the production of autoantibodies that attack the body's own tissues, causing inflammation and damage.
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