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If a man who has heterozygous type A blood and a woman with type AB blood have offspring, what are the chances that they will have a baby with type O blood?

Question

If a man who has heterozygous type A blood and a woman with type AB blood have offspring, what are the chances that they will have a baby with type O blood?

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Solution

The man with heterozygous type A blood has the genotypes IA and i. The woman with type AB blood has the genotypes IA and IB.

When they have offspring, each parent will pass on one of their alleles. The possible combinations are:

  1. IA from the man and IA from the woman, resulting in blood type A.
  2. IA from the man and IB from the woman, resulting in blood type AB.
  3. i from the man and IA from the woman, resulting in blood type A.
  4. i from the man and IB from the woman, resulting in blood type B.

As you can see, there is no combination that results in type O blood (ii). Therefore, the chances of them having a baby with type O blood is 0%.

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