What occurs early in embryonic development of female mammals to prevent "double dosing" of proteins from X chromosomes?Multiple choice question.
Question
What occurs early in embryonic development of female mammals to prevent "double dosing" of proteins from X chromosomes?Multiple choice question.
Solution
Early in the embryonic development of female mammals, a process called X-chromosome inactivation (XCI) occurs to prevent "double dosing" of proteins from X chromosomes. Here's a step-by-step explanation:
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Female mammals have two X chromosomes, one from each parent. If both X chromosomes were active, it would result in a double dose of the proteins they encode.
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To prevent this, one of the X chromosomes in each cell is randomly inactivated during early embryonic development. This process is called X-chromosome inactivation (XCI).
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XCI is controlled by the X-inactivation center (XIC), a region on the X chromosome. The XIC produces a long non-coding RNA called XIST (X-inactive specific transcript).
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XIST coats the X chromosome from which it was produced, effectively silencing most of the genes on that chromosome.
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As a result, female mammals, like males, have one functional copy of the X chromosome in each body cell. This prevents the "double dosing" of proteins from X chromosomes.
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Interestingly, the inactivated X chromosome can be seen in the nucleus as a dense region called the Barr body.
So, the
Similar Questions
X inactivation occurs early in ______ embryonic development and prevents ______ of every gene on the X chromosome.Multiple choice question.male; pleiotropyfemale; pleiotropyfemale; a double dosemale; a double dose
X inactivation occurs early in ______ embryonic development and prevents ______ of every gene on the X chromosome.
In female mammals, which X chromosome is inactivated?Group of answer choicesThe one that does not contain the gene for XistThe one that is used as a template to synthesize XistAny chromosome that does not synthesize XistThe one that encodes the gene for XistThe one that is composed of chromatin
What process in females balances the inequality of having a double dose of every gene carried on the X chromosome and leads to the expression of the paternal X allele in some cells and the maternal X allele in other cells?Multiple ChoicePleiotropyX-linked crossing overFragile X syndromeX inactivation
Which of the following statements regarding X-chromosome inactivation in female mammalian cells is correct? A) Female cells express double the amount of X-linked gene products compared to male cells B) Generally, for X-linked genes, in female tissues 1/2 of the cells express paternal alleles and 1/2 express maternal alleles C) The Barr body present in interphase nuclei represents the inactive X chromosome and is present in both male and female somatic cells D) The number of Barr bodies in female somatic cells equals the number of X chromosomes present in the cell E) Female somatic cells have only one X chromosome per cell
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