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2. Five years later she undergoes 3rd molar tooth extraction. You consider anon-steroidal anti-inflammatory drug would be the most appropriate drugtherapy for her pain.(i) What questions would you ask her before you prescribed a non-steroidal anti-inflammatory drug?(ii) What drug and dosing regimen would you recommend?(iii) What advice would you give the patient with respect to monitoringthe efficacy of the drug and its adverse effects?(iv) Consider the above questions and your answers if she were aged78 years.3. Twenty years later, she requires oral surgery for removal of a lesion in hermandible. You consider that the pain resulting from this would bemoderate to severe and of a chronic nature. The medicines which you canprescribe for acute pain are [look up AMH for these brand products:]Panadeine Forte® tablets, MS Contin® or Kapanol® tablets/capsules,Ordine® solution, Endone® tablets, Tramal® Capsules 50 mg, Palexia® IR50 mg. Check PBS prescribing by Dental Practitioners.[https://www.pbs.gov.au/pbs/home](i) Which drug and dosing regimen would you recommend?(ii) What questions might you ask the patient before you decided ontreating her?(iii) What advice (counselling) would you give the patient regarding themedication?2You should frame your answer in terms of the mechanism of action of thedrugs, their contraindications, adverse effects, pharmacokinetics and druginteractions.• You prescribe twenty 5 mg oxycodone tablets (S8). How does thisprescription differ from a usual S4 prescription?• Five days later she rings your surgery asking for a repeat prescription.What do you do?• What do you do if• a) the patient is already taking Oxycontin® 20 mg Controlledrelease tablets [1 tablet twice a day] for cancer pain];• b) is on methadone maintenance therapy (40 mg once a day) foropioid dependence.

Question

  1. Five years later she undergoes 3rd molar tooth extraction. You consider anon-steroidal anti-inflammatory drug would be the most appropriate drugtherapy for her pain.(i) What questions would you ask her before you prescribed a non-steroidal anti-inflammatory drug?(ii) What drug and dosing regimen would you recommend?(iii) What advice would you give the patient with respect to monitoringthe efficacy of the drug and its adverse effects?(iv) Consider the above questions and your answers if she were aged78 years.3. Twenty years later, she requires oral surgery for removal of a lesion in hermandible. You consider that the pain resulting from this would bemoderate to severe and of a chronic nature. The medicines which you canprescribe for acute pain are [look up AMH for these brand products:]Panadeine Forte® tablets, MS Contin® or Kapanol® tablets/capsules,Ordine® solution, Endone® tablets, Tramal® Capsules 50 mg, Palexia® IR50 mg. Check PBS prescribing by Dental Practitioners.https://www.pbs.gov.au/pbs/home Which drug and dosing regimen would you recommend?(ii) What questions might you ask the patient before you decided ontreating her?(iii) What advice (counselling) would you give the patient regarding themedication?2You should frame your answer in terms of the mechanism of action of thedrugs, their contraindications, adverse effects, pharmacokinetics and druginteractions.• You prescribe twenty 5 mg oxycodone tablets (S8). How does thisprescription differ from a usual S4 prescription?• Five days later she rings your surgery asking for a repeat prescription.What do you do?• What do you do if• a) the patient is already taking Oxycontin® 20 mg Controlledrelease tablets [1 tablet twice a day] for cancer pain];• b) is on methadone maintenance therapy (40 mg once a day) foropioid dependence.
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Solution

(i) Before prescribing a non-steroidal anti-inflammatory drug (NSAID), I would ask the patient about any known allergies to NSAIDs, history of stomach ulcers or bleeding, kidney or liver disease, asthma, or if she is taking any other medications, including blood thinners or other NSAIDs.

(ii) A common NSAID prescribed for pain after tooth extraction is ibuprofen. The usual dose is 400 mg every 4 to 6 hours as needed for pain. However, the dose can be adjusted based on the severity of the pain and the patient's overall health status.

(iii) I would advise the patient to monitor for any signs of stomach bleeding (such as black, tarry stools or vomiting blood), any new or worsening symptoms, and to report any side effects such as stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness.

(iv) In a 78-year-old patient, I would consider the same questions but also ask about any history of heart disease or high blood pressure, as NSAIDs can increase the risk of heart attack and stroke. I would also consider a lower starting dose due to potential decreased kidney function in older adults.

For the second scenario:

(i) For moderate to severe chronic pain following oral surgery, I would consider prescribing a stronger pain medication such as oxycodone (Endone®). The usual starting dose is 5 to 15 mg every 4 to 6 hours as needed for pain.

(ii) Before prescribing, I would ask the patient about any known allergies to opioids, history of substance abuse, liver or kidney disease, breathing problems, or if she is taking any other medications, including other opioids, benzodiazepines, or alcohol.

(iii) I would advise the patient about the risk of addiction and to take the medication exactly as prescribed. I would also advise her to monitor for side effects such as constipation, nausea, vomiting, drowsiness, dizziness, and respiratory depression.

For the prescription of oxycodone, it differs from a usual S4 prescription as it is a Schedule 8 controlled drug, meaning it has a high potential for abuse and addiction, and requires stricter control.

If the patient requests a repeat prescription five days later, I would assess her pain and the effectiveness of the medication before deciding whether to prescribe more.

If the patient is already taking Oxycontin® for cancer pain or is on methadone maintenance therapy, I would consider these factors before prescribing additional opioids due to the risk of overdose and respiratory depression.

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