Cholecystectomy was done in a 70 year old male. On microscopic examination, liver tissuewas found adherent to gall bladder which showed incidental finding of fine brownperinuclear granules in hepatocytes. No other pathology was noted in liver tissue. The mostlikely type of this pigment is:Select one:a. Biliverdinb. Lipochromec. Hemosiderind. Bilirubin
Question
Cholecystectomy was done in a 70 year old male. On microscopic examination, liver tissuewas found adherent to gall bladder which showed incidental finding of fine brownperinuclear granules in hepatocytes. No other pathology was noted in liver tissue. The mostlikely type of this pigment is:Select one:a. Biliverdinb. Lipochromec. Hemosiderind. Bilirubin
Solution
The pigment most likely found in this case is Hemosiderin.
Here's why:
Hemosiderin is a brownish pigment that is a byproduct of the process of breaking down hemoglobin, the molecule in red blood cells that carries oxygen. It is often found in macrophages (a type of white blood cell) in areas of the body where old red blood cells are being broken down.
In the context of the question, the presence of brown perinuclear granules in hepatocytes (liver cells) is a classic description of hemosiderin deposits. This can occur in various conditions where there is excess breakdown of red blood cells or iron overload in the body.
Biliverdin and Bilirubin are also pigments associated with the breakdown of red blood cells, but they are typically found in the gallbladder or bile ducts, not in liver cells.
Lipochrome is a yellowish pigment that is often associated with aging, but it is not typically described as forming perinuclear granules.
So, the correct answer is c. Hemosiderin.
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