The role of ubiquitin in cell cycle control is to:Group of answer choicesstimulate cyclin synthesisdephosphorylate cyclindegrade cyclinphosphorylate cyclin
Question
The role of ubiquitin in cell cycle control is to:Group of answer choicesstimulate cyclin synthesisdephosphorylate cyclindegrade cyclinphosphorylate cyclin
Solution
The role of ubiquitin in cell cycle control is to degrade cyclin.
Here's a step-by-step explanation:
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The cell cycle is a series of events that take place in a cell leading to its division and duplication. It consists of four distinct phases: G1 phase, S phase (synthesis), G2 phase (collectively known as Interphase) and M phase (mitosis).
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Cyclins are a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (CDK) enzymes.
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Ubiquitin is a small protein that exists in all eukaryotic cells. It performs its myriad functions through conjugation to a large range of target proteins. A protein that is destined for degradation by the proteasome is tagged with multiple copies of ubiquitin.
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This process of tagging is known as ubiquitination. Ubiquitination and subsequent proteasomal degradation of cyclin not only regulate progression through the different phases of the cell cycle, but also prevent accumulation of cyclin.
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Therefore, the role of ubiquitin in cell cycle control is to degrade cyclin.
Similar Questions
he enzymes involved in ubiquitinylation of cell-cycle proteins are(A) E1 and E2 only(B) E1 and E3 only(C) E1 and E4 only(D) E1, E2 and E
What role does the proteasome play in the regulation of the cell cycle?Group of answer choicesIt degrades ubiquitinated cyclin as part of a positive CDK/cyclin feedback mechanism.It degrades ubiquitinated CDK as part of a negative CDK/cyclin feedback mechanism.It degrades ubiquitinated cyclin as part of a negative CDK/cyclin feedback mechanism.It degrades ubiquitinated CDK as part of a positive CDK/cyclin feedback mechanism.
Which statement is correct regarding cyclin?Group of answer choicesIt phosphorylates CDK on Thr-160 to activate the CDK.Cyclin contains a destruction box sequence which is targeted by ubiquitin ligase.The activity of cyclin E is inhibited when bound by phosphorylated pRB.It is present at similar concentrations throughout the cell cycle.
Role of proteins involved in control of cell cycle
Increased activity of ubiquitin-proteosome system
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