Persons with Marfan syndrome have disproportionately long arms, legs, hands, and feet, a weakened aorta, and poor eyesight. All of these characteristics are due to a mutated gene (FBN1) on chromosome 15 that ordinarily specifies a functional protein called flbrillin. This is an example of _____.Group of answer choicesepistasiscodominancemultifactorialpolygenicpleiotropyNext
Question
Persons with Marfan syndrome have disproportionately long arms, legs, hands, and feet, a weakened aorta, and poor eyesight. All of these characteristics are due to a mutated gene (FBN1) on chromosome 15 that ordinarily specifies a functional protein called flbrillin. This is an example of _____.Group of answer choicesepistasiscodominancemultifactorialpolygenicpleiotropyNext
Solution
This is an example of pleiotropy. Pleiotropy occurs when one gene influences multiple, seemingly unrelated phenotypic traits, an example of which is the Marfan syndrome, where mutation in a single gene affects the skeletal system, cardiovascular system, and eyesight.
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Marfan syndrome is a dominant disorder characterized by extreme flexibility, height and weak connective tissue. However, not all of the individuals with a genotype for this condition display the phenotype. We would describe this disorder as one with ___.Group of answer choicesgenomic imprintingvariable expressivitycodominanceincomplete penetrance
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