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differentiate between gigantism and acromegaly with their sign and symptoms2. how dwarfism occurs

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differentiate between gigantism and acromegaly with their sign and symptoms2. how dwarfism occurs

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Solution 1

  1. Gigantism and Acromegaly:

Gigantism and acromegaly are both conditions that result from an overproduction of growth hormone by the pituitary gland. However, they occur at different stages of life and have different effects on the body.

  • Gigantism: This condition occurs in children or adolescents before the growth plates have closed. The excess growth hormone causes the child to grow in height significantly more than their peers, leading to an abnormally tall stature. Other symptoms can include large hands and feet, facial changes (such as a protruding jaw or enlarged nose), joint pain, and thickened skin.

  • Acromegaly: This condition occurs in adults after the growth plates have closed. Instead of increasing height, the excess growth hormone causes the bones and tissues to thicken. This can lead to enlarged hands and feet, facial changes (such as a protruding jaw or enlarged nose), joint pain, skin changes (such as thick, oily, or sweaty skin), and can also affect internal organs, leading to serious health problems if not treated.

  1. Dwarfism:

Dwarfism is a condition characterized by short stature, typically resulting from a genetic or medical condition. Most forms of dwarfism are caused by a genetic mutation that affects bone growth. The most common type, achondroplasia, is a genetic condition that affects the growth of the long bones in the arms and legs.

Symptoms of dwarfism can include a shorter than average height, shorter limbs compared to the torso, a larger head with a prominent forehead, and possible joint or back problems. Some forms of dwarfism can also lead to other health issues, such as breathing or hearing problems.

It's important to note that people with dwarfism have normal intelligence and lifespan. The condition only affects their physical growth.

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Solution 2

  1. Gigantism and Acromegaly:

Gigantism and acromegaly are both conditions that result from an overproduction of growth hormone by the pituitary gland. However, they occur at different stages of life and have different effects on the body.

  • Gigantism: This condition occurs in children or adolescents before the growth plates in their bones have closed. This leads to an abnormal increase in height and size of the body parts. Signs and symptoms may include larger than normal size for age, accelerated growth, thickened skin, excessive sweating, and joint pain.

  • Acromegaly: This condition occurs in adults after the growth plates have closed. Instead of increasing in height, the person experiences an abnormal growth in the hands, feet, and face. Signs and symptoms may include enlarged hands and feet, facial changes (such as a protruding jaw or enlarged nose), joint pain, thickened skin, and deepened voice.

  1. Dwarfism:

Dwarfism is a condition characterized by short stature, typically resulting from a genetic or medical condition. It occurs when there is a deficiency in growth hormone during childhood, or due to genetic disorders that affect bone development.

The most common cause of dwarfism is a condition called achondroplasia, a bone growth disorder that causes disproportionate dwarfism. This means that the trunk of the body is of normal size, but the arms and legs are significantly shorter.

Signs and symptoms of dwarfism can vary widely depending on the cause. They may include short stature, disproportionately short arms and legs, limited mobility at the elbows, a larger head with a prominent forehead, and spinal stenosis.

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After a blood test, an adult patient is shown to have elevated blood levels of IGF-1, and scans reveal a pituitary mass that is diagnosed as an adenoma. There is evidence of connective tissue overgrowth such as enlarged hands, feet and jaw. a. What specific region of the pituitary is involved (1 mark)? b. What is the major mediating hormone for your current observations in this patient (1 mark)? c. What is the diagnosis of this patient (1 mark)? d. What is the juvenile form of this disease that it needs to be differentiated from (1 mark)?

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