A drug that undergoes high first pass hepatic metabolism

It seems like you're asking about a drug that undergoes high first pass hepatic metabolism. This refers to the process where a drug's concentration is significantly reduced before it reaches the systemic circulation, due to the liver metabolizing a large portion of it.

Here's a step-by-step explanation:

1. Administration: The drug is administered orally and absorbed in the gastrointestinal tract.

2. Transportation to the Liver: The absorbed drug is first transported to the liver via the hepatic portal vein.

3. Metabolism in the Liver: The liver, being a major organ for drug metabolism, metabolizes a significant portion of the drug. This is the "first pass" metabolism.

4. Entry into Systemic Circulation: The remaining, unmetabolized drug then enters the systemic circulation to exert its therapeutic effect.

5. Reduced Bioavailability: Due to this high first pass metabolism, the bioavailability of the drug (the proportion that enters the circulation to have an active effect) is reduced.

An example of a drug that undergoes high first pass hepatic metabolism is Propranolol, a beta blocker used to treat high blood pressure and heart conditions.