Reabsorption of nutrients like glucose and amino acids takes place in the proximal convoluted tubule (PCT) via cotransporters that utilize secondary active transport. Which of the following would stop the reabsorption of glucose at the apical surface of the cells in the PCT?Group of answer choicesincreasing Na+ concentration in the filtrateloss of K+ leak channels at the apical surfaceloss of Na+-K+ ATPase in the basolateral surface of PCT cellsincreasing Na+ in the interstitial fluid PreviousNext
Question
Reabsorption of nutrients like glucose and amino acids takes place in the proximal convoluted tubule (PCT) via cotransporters that utilize secondary active transport. Which of the following would stop the reabsorption of glucose at the apical surface of the cells in the PCT?Group of answer choicesincreasing Na+ concentration in the filtrateloss of K+ leak channels at the apical surfaceloss of Na+-K+ ATPase in the basolateral surface of PCT cellsincreasing Na+ in the interstitial fluid PreviousNext
Solution
The correct answer is: loss of Na+-K+ ATPase in the basolateral surface of PCT cells. Here's a step-by-step explanation:
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Sodium-Potassium Pump: The Na+-K+ ATPase (also known as the sodium-potassium pump) is located on the basolateral surface of the cells in the proximal convoluted tubule (PCT). This pump uses energy from ATP to pump sodium ions (Na+) out of the cell and potassium ions (K+) into the cell.
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Sodium Gradient: This creates a concentration gradient where there is a higher concentration of sodium ions outside the cell than inside.
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Cotransport: This sodium gradient is used to power the reabsorption of glucose (and other nutrients) into the cell. This is done through a process called cotransport, where the glucose molecules are transported into the cell along with the sodium ions.
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Loss of Sodium-Potassium Pump: If the Na+-K+ ATPase were lost from the basolateral surface of the PCT cells, this would disrupt the sodium gradient. Without the sodium gradient, the cotransport of glucose into the cell would stop, halting the reabsorption of glucose.
So, in summary, the loss of Na+-K+ ATPase in the basolateral surface of PCT cells would stop the reabsorption of glucose at the apical surface of the cells in the PCT.
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