Both heavy chain genes and κ light chain genes______.1 pointare found near each other on the same chromosomebegin rearrangement by joining a V to a J regionwill have the extra J regions copied into the primary transcriptwill have the extra upstream VL regions copied into the primary transcripthave two membrane-spanning exons at the 3’ end of each of the constant regions
Question
Both heavy chain genes and κ light chain genes______.1 pointare found near each other on the same chromosomebegin rearrangement by joining a V to a J regionwill have the extra J regions copied into the primary transcriptwill have the extra upstream VL regions copied into the primary transcripthave two membrane-spanning exons at the 3’ end of each of the constant regions
Solution
The statement "Both heavy chain genes and κ light chain genes______." can be completed as follows:
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Begin rearrangement by joining a V to a J region: This is true. Both heavy chain genes and κ light chain genes undergo V(D)J recombination, a mechanism of genetic recombination that occurs in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found on B cells and T cells, respectively.
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Have two membrane-spanning exons at the 3’ end of each of the constant regions: This is also true. Both heavy chain genes and κ light chain genes have two membrane-spanning exons at the 3’ end of each of the constant regions. These exons encode the transmembrane domain and the cytoplasmic tail of the immunoglobulin heavy and light chains.
The other options are not generally true for both heavy chain genes and κ light chain genes.
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