Tumor suppressor genes put the “brakes” on the cell cycle. However, the inactivation or under-expression of tumor suppressor genes allow the cell cycle to progress indefinitely, thus promoting cancer. By which of the following mechanisms could a tumor suppressor gene be altered in a way that contributes to the development of cancer?1. Gene amplification 2. Single base pair changes 3. DNA cytosine methylation 4. Histone acetylation Group of answer choices1, 2, 41, 2, 31 and 32 and 33 and 4

The event(s) that lead(s) to inactivation of tumor suppressor genes in cancer cellsis(are)(A) gene amplification(B) promoter methylation(C) loss of heterozygosity(D) histone acetylation

When dramatic changes occur during the cell cycle, cancer may develop. Which mutation that affects the cell cycle would likely lead to the development of cancer? [B.2G]Select one:a.A mutation that suppresses the rate of mitosisb.A mutation that inhibits meiosisc.A mutation that stimulates the rate of cell divisiond.A mutation that increases the expression of tumor suppressor genes

Which processes are involved in the development of cancer?I. Mutations occur in oncogenes.II. Oncogenes prevent cancer.III. Oncogenes affect cell cycle regulatory proteins.A. I and II onlyB. I and III onlyC. II and III onlyD. I, II and III

Which mechanism is least likely to inactivate a tumor-suppressor gene?Group of answer choicesmutationchemical modificationloss of heterozygositygene duplication

. Tumour suppressor proteinsa) become hyperactive when excited by cell signalling factorsb) lose regulation when mutated, leading to oncogenesisc) normally function to stimulate cell growth and divisiond) prevent unneeded cell division