A 4 years old child was brought to Pediatric OPD with complaints of dry skin, freckles and severe sunburns after spending just a few minutes in the sun. He was diagnosed with xeroderma pigmentosu. In this genetic disease, the cell fails to repair the damaged DNA, due to a defect in the:Select one:a. Base excision repairb. Nucleotide excision repairc. Mismatch repaird. Direct repair

Which repair pathway would be used to repair a cytosine that has been turned into a uracil Group of answer choices nucleotide excision repair Base excision repair None of them. Uracil is a normal base so this is not a problem Mismatch repair

Which accurately describes the Base excision repair pathway of DNA repair?Group of answer choicesIt starts with DNA glycosylase cutting the DNA backbone. It can repair the DNA without cutting the phosphate backboneIt is the main pathway for repairing large lesions like thymine dimers.It can be used to repair missing bases or damaged bases.

Which is true about base excision repair:Group of answer choicesIt can repair pyrimidine dimers.DNA polymerase I replaces the short row of nucleotides using its 3’ to 5’ exonuclease activity.In E. coli, it repairs a mismatch in a newly synthesised DNA strand.DNA ligase is required to repair the nick formed by DNA polymerase I

Which of these DNA repair mechanisms is most likely to result in mutation?Group of answer choicesBase excision repair.Non-homologous end-joining.Mismatch repair.Nucleotide excision repair.

​​​​Vraag:Wat houdt het proces van ‘mismatch repair’ in?Het screenen van het DNA in de dochterstreng op fout ingebouwde nucleotiden en het vervangen daarvan door de juisteHet screenen van het gevormde mRNA op fout ingebouwde nucleotiden en het vervangen daarvan door de juisteHet screenen van een nieuw gevormd eiwit op fout ingebouwde aminozuren en het vervangen daarvan door de juiste