Suggest 2 factors that affect the speed of absorption of the substances in the pill.

Which is not a factor that may affect the rate of absorption of certain medications with age?Multiple ChoiceThinning of the stomach liningSlowing of peristalsisSlowing of the exit of chyme from the stomachLoss of power in mastication

AbsorptionDrug moves from site of administration into the blood, crossing at least one membrane (except if administered IV)To cross membranes, drugs must be in solution and lipid solubleInfluenced by..oRoute of administrationoDosage form – solution, tablet, suppository, etc.oSolubility of the drug – if lipid soluble, drugs cross membranes more easilyoOther factors – food in stomach, type of food in stomach; movement of drug through stomach and small intestine, pH of stomach/intestinal fluids, etc.First-pass effect – influences bioavailability of the drugBioavailability of the drug - “portion of a [drug] dose that reaches systemic circulation and is available to act on body cells

Hormones affect how fast or slow you read.Group of answer choicesTrueFalse

Which one of the following statements best describes the effects of extensive first-pass metabolism?• It affects the chemical structure of drugs by making them less potent.• It results in reduced bioavailability of orally administered drugs.• It enhances the therapeutic effects of drugs.• It leads to faster drug absorption in the body.

A rapid dissolving tablet that is absorbed through the oral mucosa avoids which of the following? A. Dedusting B. Exposure to humidity C. Disintegration phase D. First-pass effect