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A 34-year-old  female with a mechanical mitral valve has been taking warfarin  chronically to prevent thrombosis.Warfarin dose: 5 mg PO daily INR range for the past 6 months: 2.6 - 3.1 (INR goal 2.5 -  3.5)She was admitted  for ventricular tachycardi and started on Amiodarone infusion 150mg\dayWhich of these actions is considered the most safe practice ?Question 2Select one or more:A.Increase the dose of Warfarin after 3 days from initiation of amiodaroneB.Monitor INR closely C.Reduce the dose of amiodarone to 75 mgD.consider decreasing the dose of warfarin to 2.5mg \day

Question

A 34-year-old  female with a mechanical mitral valve has been taking warfarin  chronically to prevent thrombosis.Warfarin dose: 5 mg PO daily INR range for the past 6 months: 2.6 - 3.1 (INR goal 2.5 -  3.5)She was admitted  for ventricular tachycardi and started on Amiodarone infusion 150mg\dayWhich of these actions is considered the most safe practice ?Question 2Select one or more:A.Increase the dose of Warfarin after 3 days from initiation of amiodaroneB.Monitor INR closely C.Reduce the dose of amiodarone to 75 mgD.consider decreasing the dose of warfarin to 2.5mg \day

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Solution

The safest practice in this scenario would be to closely monitor the INR (International Normalized Ratio). This is because both Warfarin and Amiodarone can interact and potentially increase the risk of bleeding. Amiodarone can enhance the anticoagulant effect of Warfarin, and therefore, the INR levels can increase. Regular monitoring of INR will help to ensure that it stays within the therapeutic range and prevent complications.

While it might be necessary to adjust the doses of Warfarin or Amiodarone based on the INR results, any changes should be made cautiously and under the supervision of a healthcare provider. Therefore, options A, C, and D may also be considered, but only after careful monitoring and evaluation.

Please note that this advice is based on general clinical guidelines and the specific needs of the patient may vary. Always consult with a healthcare provider for personalized medical advice.

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