How many transcription factors in the human genome?

The exact number of transcription factors in the human genome is not definitively known and can vary depending on the criteria used to define a transcription factor. However, it is generally estimated that there are between 1,400 to 1,700 transcription factors in the human genome. This estimate is based on the number of genes that encode proteins with DNA-binding domains, which are typically required for transcription factor function.