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Describe how water-soluble and lipid soluble hormones exert their action on target cells.

Question

Describe how water-soluble and lipid soluble hormones exert their action on target cells.

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Solution

Water-soluble and lipid-soluble hormones exert their actions on target cells differently due to their molecular structure and solubility characteristics.

  1. Water-Soluble Hormones: These hormones are not able to pass through the cell membrane because it is lipophilic (fat-loving) and hydrophobic (water-hating). Therefore, these hormones bind to receptors located on the surface of the target cell. This binding activates a second messenger, usually a molecule called cyclic AMP (cAMP), inside the cell. The second messenger then triggers a series of reactions inside the cell that ultimately lead to the cell's response to the hormone. This process is known as the second messenger system.

  2. Lipid-Soluble Hormones: These hormones, on the other hand, are able to pass through the cell membrane due to their lipophilic nature. Once inside the cell, they bind to receptors located in the cytoplasm or nucleus. The hormone-receptor complex then moves into the nucleus, where it binds to specific regions of the cell's DNA and acts as a transcription factor, regulating gene expression. This leads to the

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