he development of tolerance to cannabis involvesGroup of answer choicesdesensitization of CB1 receptorsdown-regulation of CB1 receptorsup-regulation of CB1 receptorsA and BA and C
Question
he development of tolerance to cannabis involvesGroup of answer choicesdesensitization of CB1 receptorsdown-regulation of CB1 receptorsup-regulation of CB1 receptorsA and BA and C
Solution
The development of tolerance to cannabis involves both desensitization and down-regulation of CB1 receptors.
Here's a step-by-step explanation:
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Desensitization of CB1 receptors: This is a process where the receptors become less responsive to the substance (in this case, cannabis). After repeated exposure to cannabis, the CB1 receptors do not respond as strongly as they initially did, leading to a decreased effect. This is one way the body develops tolerance.
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Down-regulation of CB1 receptors: This is another process that contributes to the development of tolerance. Down-regulation refers to the decrease in the number of CB1 receptors. After repeated exposure to cannabis, the body may reduce the number of CB1 receptors, which means more cannabis is needed to achieve the same effect.
So
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