The T cell receptor (TCR):Select one alternative:Has enormous binding diversity created by gene segment rearrangement.Consists of 2 protein chains, each with variable and constant domains.Contains only one antigen-binding site.All of the above

T cell maturation and development of their antigen-specific receptors takes place in the . B cells mature in the where they also develop their specificity to a single antigen. This specificity in both B and T cells is made possible through genetic . The genes that code for the variable regions of both B and T cell receptors are cut and spliced during the process of both cells. Because genetic rearrangement occurs at the level of the rather than in the RNA following , the changes are permanent, resulting in each cell being capable of binding to a single antigen in a pool of up to 1018 possible variations. B cell receptors are that are comprised of four and have two identical antigen binding sites. The region of the immunoglobulin is embedded in the cell membrane, and the variable regions are facing outward in order to bind to their potential antigenic match. Unlike B cell receptors, T cell receptors are comprised of two polypeptides and have antigen binding site(s) that is exposed. Like B cell receptors, their specificity to a single antigen is determined any encounters with antigens.

Which of the following mechanisms produces the MOST diversity in T cell receptors?

Studies of the structure of the T-cell receptor indicate it has significant homologies to the _________ of immunoglobulins (antibodies), with the _______ peptides resembling the heavy chain.1 pointarms; α and γarms; β and δstem; α and γstem; β and δ

What must protein antigens be processed into and bound onto to be recognised by a T-Cell Receptor?

Rearrangement of the T cell receptor _______ gene results in the deletion of the T cell receptor _____ gene.1 pointα; γα; δβ; γβ; δδ; α