Neurulation refers to the early formation of the nervous system in vertebrate embryos. It begins when the notochord, a rodlike mesodermal structure, induces neural tube and neural crest cell formation in a different germ layer called the ectoderm.Neural tube defects (NTDs) arise from abnormalities in the development of the neural tube and can range from mild to severe, depending on which portion of the tube is affected. Spina bifida, a form of NTD, is divided into three categories. The most serious subclassification of spina bifida is myelomeningocele, which occurs when the lower spine fails to close and leaves the spinal cord and nerve roots in the lower back damaged and exposed.NTDs are thought to be caused in part by folate deficiency. Folate plays a critical role in normal cell division and growth as it is a necessary coenzyme for DNA synthesis and methylation. Mutations in several genes involved in folate metabolism have been associated with an increased risk for NTDs. It has been hypothesized that folate decreases NTD risk by ameliorating oxidative stress, thereby reducing damage to developing cells in the embryo. Certain maternal conditions, such as high blood glucose, increase the risk of NTD development by enhancing embryonic oxidative stress during crucial developmental periods.A study was conducted to examine how supplementation with folic acid, the dietary form of folate, affected pregnant women who were identified with preexisting diabetes, pregestational obesity (another risk factor for NTD), or no preexisting conditions (control group). Higher folic acid intake decreased the incidence of embryonic NTDs among pregnant women with diabetes but no significant effect was found for pregnant women who were obese.Adapted from Parker, S.E., Yazdy, M.M., Tinker, S.C., Mitchell, A.A., & Werler, M.M. (2013). The impact of folic acid intake on the association among diabetes mellitus, obesity, and spina bifida. American journal of obstetrics and gynecology, 209(3), 239.e1–239.e2398. Question 29Compared to newborns without NTDs, a newborn diagnosed with myelomeningocele would most likely have exhibited which of the following during gestation?A.Lower frequency of cell damage at critical developmental periodsB.Lower cellular concentrations of free radicalsC.Higher levels of anti-apoptotic transcription factorsD.Higher incidence of apoptosis
Question
Neurulation refers to the early formation of the nervous system in vertebrate embryos. It begins when the notochord, a rodlike mesodermal structure, induces neural tube and neural crest cell formation in a different germ layer called the ectoderm.Neural tube defects (NTDs) arise from abnormalities in the development of the neural tube and can range from mild to severe, depending on which portion of the tube is affected. Spina bifida, a form of NTD, is divided into three categories. The most serious subclassification of spina bifida is myelomeningocele, which occurs when the lower spine fails to close and leaves the spinal cord and nerve roots in the lower back damaged and exposed.NTDs are thought to be caused in part by folate deficiency. Folate plays a critical role in normal cell division and growth as it is a necessary coenzyme for DNA synthesis and methylation. Mutations in several genes involved in folate metabolism have been associated with an increased risk for NTDs. It has been hypothesized that folate decreases NTD risk by ameliorating oxidative stress, thereby reducing damage to developing cells in the embryo. Certain maternal conditions, such as high blood glucose, increase the risk of NTD development by enhancing embryonic oxidative stress during crucial developmental periods.A study was conducted to examine how supplementation with folic acid, the dietary form of folate, affected pregnant women who were identified with preexisting diabetes, pregestational obesity (another risk factor for NTD), or no preexisting conditions (control group). Higher folic acid intake decreased the incidence of embryonic NTDs among pregnant women with diabetes but no significant effect was found for pregnant women who were obese.Adapted from Parker, S.E., Yazdy, M.M., Tinker, S.C., Mitchell, A.A., & Werler, M.M. (2013). The impact of folic acid intake on the association among diabetes mellitus, obesity, and spina bifida. American journal of obstetrics and gynecology, 209(3), 239.e1–239.e2398. Question 29Compared to newborns without NTDs, a newborn diagnosed with myelomeningocele would most likely have exhibited which of the following during gestation?A.Lower frequency of cell damage at critical developmental periodsB.Lower cellular concentrations of free radicalsC.Higher levels of anti-apoptotic transcription factorsD.Higher incidence of apoptosis
Solution
D. Higher incidence of apoptosis
Myelomeningocele, a severe form of spina bifida, occurs when the lower spine fails to close properly during gestation, leading to damage and exposure of the spinal cord and nerve roots. This defect is a result of abnormal development of the neural tube, which is likely to involve increased cell death, or apoptosis, during critical developmental periods. Therefore, compared to newborns without Neural Tube Defects (NTDs), a newborn diagnosed with myelomeningocele would most likely have exhibited a higher incidence of apoptosis during gestation.
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