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Daisy’s collaborator, Catalina also travelled from Melbourne to La Paz at the same time. While Daisy was feeling tired and unwell, Catalina felt no such effects. In talking with Catalina, Daisy found out that Catalina is Bolivian and actually grew up in La Paz and has family in the local area around La Paz who has been there for generations.Based on what you know about adaptations of different human populations that have lived at altitude, which of the following is the most likely explanations for the different responses that Catalina had compared to Daisy on arriving at high altitude? (Select all that are correct. There may be one or more correct options)Group of answer choicesAltered mitochondria energeticsIncreased anaerobic metabolism capacitiesGenetics varianceHigher hematocrit levels

Question

Daisy’s collaborator, Catalina also travelled from Melbourne to La Paz at the same time. While Daisy was feeling tired and unwell, Catalina felt no such effects. In talking with Catalina, Daisy found out that Catalina is Bolivian and actually grew up in La Paz and has family in the local area around La Paz who has been there for generations.Based on what you know about adaptations of different human populations that have lived at altitude, which of the following is the most likely explanations for the different responses that Catalina had compared to Daisy on arriving at high altitude? (Select all that are correct. There may be one or more correct options)Group of answer choicesAltered mitochondria energeticsIncreased anaerobic metabolism capacitiesGenetics varianceHigher hematocrit levels

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Solution

The most likely explanations for the different responses that Catalina had compared to Daisy on arriving at high altitude are:

  1. Altered mitochondria energetics: People who live at high altitudes may have adaptations in their mitochondria, the energy-producing structures in cells, that allow them to use oxygen more efficiently.

  2. Genetics variance: Genetic differences could also play a role. Some populations have lived at high altitudes for thousands of years and may have evolved genetic adaptations to the low-oxygen environment.

  3. Higher hematocrit levels: Hematocrit is the proportion of your blood that is made up of red blood cells. Red blood cells carry oxygen, so having a higher hematocrit level can help your body get the oxygen it needs in a low-oxygen environment. People who live at high altitudes often have higher hematocrit levels than people who live at sea level.

Increased anaerobic metabolism capacities is not a likely explanation. Anaerobic metabolism is the creation of energy through the combustion of carbohydrates in the absence of oxygen. This occurs when your lungs cannot put enough oxygen into the bloodstream to keep up with the demands of your muscles for energy. It is not a sustainable way of producing energy and is not likely to be a long-term adaptation to living at high altitudes.

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