It seems like you didn't provide a complete question. However, I can explain how endogenously produced miRNAs silence gene expression in animal cells.

1. MicroRNAs (miRNAs) are small non-coding RNA molecules that are produced within the cell (endogenously).

2. These miRNAs are transcribed from DNA but do not code for proteins. Instead, they function in RNA silencing and post-transcriptional regulation of gene expression.

3. The process begins with the transcription of a miRNA gene by RNA polymerase II or III to produce a primary miRNA (pri-miRNA).

4. This pri-miRNA is then processed by an enzyme called Drosha to produce a precursor miRNA (pre-miRNA).

5. The pre-miRNA is exported from the nucleus to the cytoplasm, where it is further processed by an enzyme called Dicer to produce a mature miRNA.

6. The mature miRNA is incorporated into a protein complex called the RNA-induced silencing complex (RISC).

7. The miRNA within the RISC pairs with complementary sequences in the messenger RNAs (mRNAs) of certain genes.

8. Once bound, the RISC can inhibit the translation of the mRNA into a protein, effectively silencing the gene.

9. This process allows the cell to regulate gene expression in response to changing conditions.

Please provide the complete question if you need more specific information.

Question

It seems like you didn't provide a complete question. However, I can explain how endogenously produced miRNAs silence gene expression in animal cells.

1. MicroRNAs (miRNAs) are small non-coding RNA molecules that are produced within the cell (endogenously).

2. These miRNAs are transcribed from DNA but do not code for proteins. Instead, they function in RNA silencing and post-transcriptional regulation of gene expression.

3. The process begins with the transcription of a miRNA gene by RNA polymerase II or III to produce a primary miRNA (pri-miRNA).

4. This pri-miRNA is then processed by an enzyme called Drosha to produce a precursor miRNA (pre-miRNA).

5. The pre-miRNA is exported from the nucleus to the cytoplasm, where it is further processed by an enzyme called Dicer to produce a mature miRNA.

6. The mature miRNA is incorporated into a protein complex called the RNA-induced silencing complex (RISC).

7. The miRNA within the RISC pairs with complementary sequences in the messenger RNAs (mRNAs) of certain genes.

8. Once bound, the RISC can inhibit the translation of the mRNA into a protein, effectively silencing the gene.

9. This process allows the cell to regulate gene expression in response to changing conditions.

Please provide the complete question if you need more specific information.

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