Give a single base pair substitution (write out the codon before and after mutation) that could cause a truncation of this peptide. If there are multiple ways, you only need to identify one. (1 mark)
Question
Give a single base pair substitution (write out the codon before and after mutation) that could cause a truncation of this peptide. If there are multiple ways, you only need to identify one. (1 mark)
Solution
To answer this question, I need to know the sequence of the peptide or the DNA/RNA sequence that codes for it. A truncation mutation usually occurs when a base pair substitution results in a premature stop codon, which halts protein synthesis.
For example, if we have a codon sequence like GAA which codes for the amino acid Glutamate, a single base pair substitution changing it to UAA would result in a stop codon, truncating the peptide.
So, the codon before mutation is GAA (Glutamate) and after mutation is UAA (Stop).
Please note that the actual codon sequence may vary depending on the specific peptide sequence you are referring to.
Similar Questions
A mutation that results in a codon that codes for the same amino acid.Group of answer choicessilent mutationnucleotide substitutionpoint mutationnonsense mutationdeletioninsertionmissense mutationframeshift mutationNext
What type of mutation occurs when a base substitution results in the change of a single amino acid in a protein?Multiple choice question.NonsenseMissenseFrameshiftSense
The addition or deletion of a nucleotide base pair can result in a ____.nonsense mutationsilent mutationpoint mutationframeshift mutation
A nucleotide substitution that has no observable effect on the phenotype.Group of answer choicessilent mutationframeshift mutationmutationnonsense mutationinsertiondeletionpoint mutationmissense mutation
A mutation converts an AGA codon to a TAA codon . This mutation is a:Termination mutationNoncoding mutationNonsense mutationMissense mutation
Upgrade your grade with Knowee
Get personalized homework help. Review tough concepts in more detail, or go deeper into your topic by exploring other relevant questions.