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An epithelial cell in the upper respiratory tract was infected with an enveloped virus, such as influenza virus.  Upon entering the host cell, the viral life cycle was initiated and the host cell machinery was used to synthesize new viral components.  Given this information, which of the following statements is LEAST likely to be true?A.Inhibition of protein synthesis in the cytosol would limit the assembly of new viruses.B.Disruption of trafficking between the Golgi apparatus and cell surface would result in the production of fewer viral glycoproteins.C.Inhibition of lysosomal trafficking would prevent new viruses from being released.D.Disruption of protein synthesis in the rough endoplasmic reticulum would inhibit the release of new viruses.

Question

An epithelial cell in the upper respiratory tract was infected with an enveloped virus, such as influenza virus.  Upon entering the host cell, the viral life cycle was initiated and the host cell machinery was used to synthesize new viral components.  Given this information, which of the following statements is LEAST likely to be true?A.Inhibition of protein synthesis in the cytosol would limit the assembly of new viruses.B.Disruption of trafficking between the Golgi apparatus and cell surface would result in the production of fewer viral glycoproteins.C.Inhibition of lysosomal trafficking would prevent new viruses from being released.D.Disruption of protein synthesis in the rough endoplasmic reticulum would inhibit the release of new viruses.

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Solution

The statement that is LEAST likely to be true is C. Inhibition of lysosomal trafficking would prevent new viruses from being released. Lysosomes are involved in breaking down and recycling cellular components, but they are not directly involved in the release of new viruses. The release of new viruses, particularly enveloped viruses like the influenza virus, typically involves the Golgi apparatus and the cell membrane, not the lysosomal pathway. Therefore, inhibiting lysosomal trafficking would not necessarily prevent new viruses from being released.

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